ST. LOUIS — Two years ago, Jamie Reed was adjusting to a new position at Washington University, working in cancer research. In her spare time, she taught swimming lessons and tended to her garden.

She had left her old job as the case manager at Washington University’s Transgender Center at St. Louis Children’s Hospital. Three months later, in February 2023, Reed sounded an alarm about her former employer.

Her public allegations of malpractice reverberated throughout the country. She charged that doctors introduced medical interventions without informed parental consent, that mental health issues weren’t adequately addressed and that minors were regularly referred for surgery.

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The mother of five instantly became a lightning rod for a burgeoning debate about how transgender people, especially young people, should be treated.

Since then, Reed’s life — like her view of transgender care — has radically changed. She’s become a high-profile voice for opponents of gender-affirming treatment. She has spoken in court and at conferences across the United States and abroad. She’s been profiled in the New York Times and interviewed by Dr. Phil.

When Reed left the pediatric transgender center in late 2022,...

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